Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia

Preeclampsia is Characterized by Fetal NK Cell Activation and a Reduction in Regulatory T Cells

PROBLEM Preeclampsia affects 3-17% of pregnancies worldwide and has serious consequences for both the mother and the fetus. As maternal-fetal immune tolerance is bidirectional, fetal immunopathology may play a significant role in the pathogenesis of pregnancy disorders. Nevertheless, the impact of preeclampsia on the fetal immune system is unclear. METHOD OF STUDY In this case-control study, ...

Evaluation of Exhausted Regulatory T Cells in Preeclampsia

Background: The development of a maternal immune response to fetal antigens and deficiency in regulatory T-cells (Tregs) may lead to preeclampsia. A plausible explanation for the reduced Treg cell function in women with preeclampsia is the presence of exhausted Treg cells which express CD279 or programmed cell death receptor-1 (PD-1), a negative regulatory molecule associated w...

Neutralization of interleukin-17 produced by gamma delta T cells constrains inflammation in experimental biliary atresia

Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27

Background and purpose: In multiple sclerosis (MS) and its murine model, experimental autoimmune encephalomyelitis (EAE), chronic inflammation damages the myelin of central nervous system. Recently, interleukin-27 (IL-27) has been recognized as a feasible choice for treatment of autoimmune diseases such as MS due to its anti-inflammatory properties. However, the underlying mechanisms have not y...

The Role of Appendix in the Management of Biliary Atresia Associated with Bowel Atresia

Biliary atresia is characterized by the progressive obliteration of extra- and intrahepatic biliary duct system leading to the obstruction of bile flow in infancy. The cause(s) of biliary atresia remain unclear and many surgical options for bypassing the atretic segment have been described.1-3 Biliary atresia may be associated with small bowel atresia.  The surgical interventions for biliary dr...